Category: qhxhixfebysvahcd

Category: qhxhixfebysvahcd Mavericks’ Matthews likely out for season with leg fracture

first_imgDon’t miss out on the latest news and information. Steam emission over Taal’s main crater ‘steady’ for past 24 hours FILE – Wesley Matthews #23 of the Dallas Mavericks shoots the ball against the Indiana Pacers during the game at Bankers Life Fieldhouse on December 27, 2017 in Indianapolis, Indiana. Andy Lyons/Getty Images/AFPDALLAS — Mavericks guard Wesley Matthews has a broken bone in his lower right leg and is likely to miss the rest of the season.The team says the 31-year-old Matthews was injured in the first quarter against Memphis on Saturday. The nine-year veteran played into the fourth quarter of the Mavericks’ 114-80 win.ADVERTISEMENT It’s too early to present Duterte’s ‘legacy’ – Lacson Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award UK plans Brexit celebrations but warns businesses may suffer Nueva Ecija warehouse making fake cigarettes raided, 29 Chinese workers nabbed LATEST STORIES Hawks lose Bazemore for remainder of season with knee injury View commentscenter_img Jiro Manio arrested for stabbing man in Marikina GALLERY: Barangay Ginebra back as PBA Governors’ Cup kings Phivolcs records 2 ‘discrete weak ash explosions’ at Taal Volcano Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Sports Related Videospowered by AdSparcRead Next The injury was announced Monday as a fracture to the right proximal fibula, just below the knee. Dallas (21-46) already has been eliminated from playoff contention.Matthews is averaging 12.7 points in his third season with Dallas since signing a $70 million, four-year contract in 2015. It was the same summer that DeAndre Jordan backed out on an agreement to join the Mavericks, a decision that resulted in more money for Matthews.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkAfter signing with Dallas, Matthews returned much sooner than expected after tearing an Achilles tendon late in his final season with Portland. MOST READ Sea turtle trapped in net freed in Legazpi Citylast_img read more

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Category: qhxhixfebysvahcd Six new signings to watch in Serie A

first_imgLights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Palace OKs total deployment ban on Kuwait OFWs Position: StrikerOn loan from: Juventus (ITA)Argentine international striker Higuain scored 40 goals in two seasons at Juventus, but with the arrival of Ronaldo has opted to head for rivals AC Milan on a one-year loan deal worth a reported 18 million euros ($21 million) that gives the Serie A club the option to buy the striker next summer for a further 36 million euros. Higuain’s arrival has revived enthusiasm around Milan after a troubled period marked by on-pitch embarrassment and financial woes. Last season they scored just 56 league goals as they finished sixth despite spending over 200 million euros ($233 million) on new players. This season they have spent a more modest 81 million euros so far.Leonardo Bonucci (Juventus)Age: 31Position: Centre-backPrevious club: AC Milan (ITA)Italy international defender Bonucci went back to Turin, where he previously won six Serie A titles and played in both of their lost European finals, after just one underwhelming season at Milan. The 31-year-old admitted that he left Juve in a fit of pique after falling out with Allegri in 2017, but “missed home” and wanted to return after burying the hatchet with the coach.Simone Verdi (Napoli)Age: 26 Peza offers relief to ecozone firms In fight vs corruption, Duterte now points to Ayala, MVP companies as ‘big fish’ Position: ForwardPrevious club: Bologna (ITA)The Italian international forward was one of Carlo Ancelotti’s first signings as Napoli coach coming in for 23 million euros despite the Serie A runners-up trailing behind their rivals in the transfer market spending. A versatile player Verdi scored ten goals last season for Bologna who he joined after Carpi were relegated in 2016, having also previous played for Torino and his boyhood club AC Milan.Javier Pastore (Roma)Age: 29Position: MidfielderPrevious club: Paris Saint-Germain (FRA)Argentinian attacking midfielder Pastore returned to Italy on a 24.7-million-euro ($28.8 million) deal. The 29-year-old previously played in Serie A with Palermo from 2009-11 and was named the league’s young player of the season in 2010. The gifted playmaker was the first major signing PSG made in 2011 after being taken over by their Qatari owners. Pastore’s move back to Italy comes with Paris Saint-Germain under pressure from UEFA to balance their books after signing Neymar and Kylian Mbappe in blockbuster deals last season, sparking an audit of their financial affairs.Radja Nainggolan (Inter Milan)Age: 30 LATEST STORIES ‘High crimes and misdemeanors’: Trump impeachment trial begins Clarkson arrives in Indonesia just in time to watch PH team With the transfer window slamming shut in Italy at 19:00 GMT on Friday, Serie A teams have time to overtake the 1.037 billion euros spent last summer.Here AFP Sport picks out six new signings to watch in the coming campaign.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSJapeth Aguilar wins 1st PBA Finals MVP award for GinebraSPORTSTim Cone still willing to coach Gilas but admits decision won’t be ‘simple yes or no’Cristiano Ronaldo (Juventus)Age: 33 MOST READ Gov’t in no rush to rescue animals in Taal Nadine Lustre’s phone stolen in Brazil Judy Ann’s 1st project for 2020 is giving her a ‘stomachache’ Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Position: ForwardPrevious club: Real Madrid (ESP)Reigning seven-time Italian champions Juventus had the biggest scoop of the summer in five-time Ballon d’Or winner Ronaldo, who arrived from European champions Real Madrid in a shock 100 million euro ($117 million) deal. Massimiliano Allegri’s side are counting on the evergreen Portuguese superstar to help win the Champions League. Ronaldo has been the bogey man in Europe for Juventus in recent years, scoring 10 in seven games against the Serie A side for Real Madrid as the Spaniards romped to three straight Champions League titles. Ronaldo has thwarted Juve’s attempts to bag their first Champions League since 1996 in both of the last two seasons, earning a standing ovation from the Turin crowd for his superb overhead bicycle kick last season and scoring a brace in the 2017 final as Madrid thumped the Italians 4-1.Gonzalo Higuain (AC Milan)Age: 30ADVERTISEMENT Juventus’ forward from Portugal Cristiano Ronaldo scores a goal during the friendly football match between Juventus A and Juventus B at Villar Perosa, on August 12, 2018 at Villar Perosa. / AFP PHOTO / Isabella BonottoCristiano Ronaldo’s move to Juventus has injected an air of expectation into the Italian championship not felt in decades while spending has smashed the one billion euro mark with more than a day still to go before the transfer window closes.Champions Juventus top the spree with 235 million euros ($265 million) invested in new players—more than double rivals AS Roma and Napoli—as for the second straight year Serie A are the only one of the top five European leagues to keep pace with the big-spending English Premier League.ADVERTISEMENT Position: MidfielderPrevious club: Roma (ITA)The controversial Belgium international, looking for a new challenge after being snubbed for the World Cup, links up again with former Roma coach Luciano Spalletti, as Inter look to improve on a fourth-place in Serie A and compete in the Champions League for the first time since 2011-12. “I think I had my best season under Spalletti and I hope to do just as well here,” said Nainggolan who arrives on a four-year contract worth 38 million euros. “I hope we can do well both in Serie A and the Champions League because Inter have a proud history. Hopefully we’ll get back to those heights again now.”Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. DepEd’s Taal challenge: 30K students displaced View commentslast_img read more

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Category: qhxhixfebysvahcd $148M for Small Business Bureau in 2018

first_imgIn 2018, the Small Business Bureau (SBB) intends to implement a programme, where it will register companies that meet certain criteria with regard to standards and quality. These companies would form a list of companies that the Bureau can recommend to larger companies looking to sub-contract or contract Small-to-Medium Enterprises (SME.)This was announced by Business Minister Dominic Gaskin during his budget presentation to the National Assembly. Minister Gaskin noted that over the years, the SBB has demonstrated the capacity to manage business development programmes successfully.He also disclosed that advertisements will be placed at the Bureau on behalf of these companies to promote them to larger enterprises.“These larger enterprises can contact the Bureau whenever a business opportunity arises, and the Bureau would then recommend the qualified companies in this sector of activity. If successful, this can be a great programme to promote the small businesses of Guyana,” Minister Gaskin explained.Additionally, $100 million has been allocated towards the establishment of the Small Business Development Fund. This will serve as a revolving loan fund to address the needs of businesses that cannot meet the requirements of the traditional banking system.According to the Department of Public Information, Minister Gaskin said the effective revolving nature of the fund will limit the erosion of its capital. This, he said, will be achieved through careful screening of applicants prior to referral to the programme; frequent review of the performance of the revolving fund; favourable interest rates; and shorter repayment periods (not more than one year) to allow for timely revolving of funds.last_img read more

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Category: qhxhixfebysvahcd Former Revelstoke mayor talks dams in the Peace

first_imgBy Christine Rumleskie But, Roe says Parker’s speech will take a non-partisan approach, and will simply be an educational seminar for participants. [asset|aid=2870|format=mp3player|formatter=asset_bonus|title=170457914077d65e10286cebbbb325f3-Steve Roe 1_1_Pub.mp3] Parker’s lecture is called, “Lessons from the Past: One Mayor’s Experience with the Revelstoke Canyon Dam.”Everyone is invited to attend the free event at the Northern Lights College in Fort St. John, on May 12th at 7 o’clock.Advertisement The former mayor of Revelstoke will be coming to Fort St. John next week, to talk about his experience dealing with hydroelectric dams.Sid Parker will be holding a lecture at the Northern Lights College.- Advertisement -NLC spokesperson Steve Roe says the educational speech comes at a convenient time. [asset|aid=2869|format=mp3player|formatter=asset_bonus|title=170457914077d65e10286cebbbb325f3-Steve Roe 2_2_Pub.mp3] Roe says he predicts there will be a lot of residents interested in the lecture, because of the looming Site-C project. Advertisementlast_img read more

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Category: qhxhixfebysvahcd Arsenal one of FOUR European sides chasing Chelsea star

first_img Petr Cech 1 Arsenal, Paris Saint-Germain, Inter Milan and Roma are all interested in signing Chelsea shot-stopper Petr Cech this summer, according to reports in France.The 32-year-old goalkeeper, who is valued at around £10m, is attracting interest across Europe – according to French newspaper Le Figaro.Cech has made 493 appearances for the Blues since joining from Rennes in June 2004 for £7m, though the return of Thibaut Courtois, following a successful loan spell at Atlético Madrid, has resulted in him accumulating just a handful of appearances this season.Following the emergence of David Ospina in the second half of this season, Cech would face similar competition at Arsenal, and former Chelsea assistant Ray Wilkins believes the Blues will not be keen on selling the Czech ‘keeper to Premier League rivals.Therefore, a move to Paris Saint-Germain or Roma would seem more likely, with Champions League football on offer at both clubs.last_img read more

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Category: qhxhixfebysvahcd Island’s fox-breeding program ends

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREGame Center: Chargers at Kansas City Chiefs, Sunday, 10 a.m.“Come on, it’s OK,” Dave Garcelon, president of the Institute for Wildlife Studies, whispered to the fox. The setting sun cast a long shadow behind the cat-size animal as it looked around its new home on the western edge of Santa Cruz Island. All the captive-bred island fox had to do was scamper from the open kennel and run into the grass-covered hills where hundreds of other tiny island foxes are living. One minute passed. Two. The fox sniffed the ground and the air and took it all in but still didn’t budge. Finally, with a bit of prodding, it ran into the hills away from the crowd of scientists, politicians and journalists gathered to watch the momentous event. Nine other endangered island foxes would join it before the end of the day, marking the end of captive breeding on Santa Cruz and the start of what biologists hope is the recovery of the species. WILDLIFE: Biologists believe the population of about 300 is enough for comeback of the small animals. By Zeke Barlow SCRIPPS HOWARD NEWS SERVICE VENTURA – After a life inside a fence, the fox had found freedom. The only thing was, it didn’t want to go. The pioneering program to re-establish the foxes found only on the Channel Islands began six years ago. Biologists have now decided the population of about 300 foxes should be enough to stop the breeding program and let the foxes rebound naturally. “This is a great success story,” said Garcelon, whose organization bred more than 85 pups under a contract from the Channel Islands National Park and The Nature Conservancy, which owns 76 percent of the island. And their population should continue to grow. The fox populations on Santa Cruz, San Miguel and Santa Rosa islands nearly crashed in the past decade as non-native golden eagles feasted on the 5-pound foxes, which were unaccustomed to predators swooping down from the sky. Bald eagles, which mainly eat marine life, had traditionally occupied the island, but years of DDT poisoning decimated the population. With no bald eagles to compete for territory, and lured by the presence of non-native pigs and their edible piglets on Santa Cruz Island, golden eagle populations grew as the foxes dwindled. Only about 15 foxes were left on Santa Rosa and San Miguel islands and fewer than 100 on Santa Cruz. In 1999, biologists started trapping and relocating the golden eagles. Three years later, they started reintroducing bald eagles and breeding foxes. Bald eagles are now nesting on the islands. In 2005, a New Zealand company was hired to kill every one of the 5,036 pigs on Santa Cruz Island. The controversial process led an animal rights group to file a lawsuit to stop it, but it was unsuccessful, and the last pig was killed in 2006. Once the stage was set, breeding still wasn’t as easy as setting up a date between two young foxes. “It was dicey,” said park biologist Tim Coonan, who has been working with the foxes for years. There was a steep learning curve in getting the foxes to mate because nobody had bred them before. They learned that females preferred to have a number of males to choose from and that they only started ovulating when a male was present. Females would sometimes get roughed up during intense mating sessions; still, they mated for life. DNA was gleaned from blood samples to make sure no inbreeding occurred. On Santa Cruz, 18 “founding” foxes produced 85 offspring. On San Miguel Island, eight adults were used to beef up the population. Two of the founding female foxes on San Miguel are so old – about 12 years – they are too frail to return to the wild, so biologists will keep them the remainder of their lives. They’ve earned the moniker “The Golden Girls.” Visitors to Santa Cruz’s Prisoner’s Cove campsite have a good chance of seeing the gregarious creatures that scamper about the area. They’ve eaten boxes of cookies, run across sleeping campers and urinated on tents there. “They are like campground dogs,” said Coonan, who half-joked about issuing squirt guns with onion water to keep the foxes at bay. About 30 percent of the foxes on the islands have radio collars, which will be used to track the population in studies that are expected to continue for years. The foxes are considered an indicator species for the islands that help biologists monitor the health of the ecosystem.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more

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Category: qhxhixfebysvahcd Taking turf war off the street, onto the court

first_imgNORTH HOLLYWOOD – Amid the children playing ball and tennis players with their racquets, the gangsters squared off – but their only fight was who’d take home the biggest trophy. Their sport on a sunny Saturday morning was handball, learned growing up in neighborhood parks and often refined behind bars. They bickered over who had the better serve, whose feet were faster, who talked the best game. They swore, cheered, yelled and boasted. These men and boys, dressed in their colors, flashing their tats, played hard and played fair on the courts of North Hollywood Park. They had fun. “You set ’em up, go in the front and hit it way back,” said Javier, a 31-year-old whose friends call him “Sharky” and who learned the game in prison. “He runs back, hits it, you drop it down in the front for the kill.” AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREOregon Ducks football players get stuck on Disney ride during Rose Bowl event“Whatever, dog, just slap the hell out of it,” said his friend Serge, who also hangs around with the boys of Culver City and favors a more muscular approach to the game. “I don’t slap,” Sharky shot back. “I’ve got strategy, dog.” After a hard winter that set tensions rising on the street, gang intervention advocates decided a little healthy competition would help cool tempers and resolve some lingering beefs. North Hills-based Communities in Schools partnered with organizations in Culver City and Boyle Heights to invite gang members to spend some time playing together, rather than sitting idle on a street corner. More than 100 people turned out, from teens to veteranos who still had game left in their stiff knees and scarred arms. Jojo Crespin, who turned heads all morning, took home first place in the singles, Mario Mendoza won second and Andy Segura earned the third-place trophy. Organizer William “Blinky” Rodriguez, Communities In Schools’ executive director, counted 12 different gangs, a small contingent of ladies, Councilman Tony Cardenas, a senior probation officer, several ministers and a Los Angeles Police Department deputy chief among the audience and players. “The gang lifestyle is a dead-end street,” said Deputy Chief Michel Moore, who heads the LAPD Valley Bureau. “If we can redirect them to do something meaningful, then they’re part of a society we welcome. … If this causes even one of these guys to not go down that destructive path, it’s a success.” The tough young men who came to play agreed. Charles “Boxer” Lewin has been shot, stabbed and incarcerated for 17 years. He’s got a huge scar on his back and tattoos all the way across his head, making him look like a very tough customer. And there he was, flexing on the sideline, boasting to all who’d listen that he’d bring home the title. “I’ll come out and party with the guys who are supposed to be my enemies, play some ball, smack it around,” said Lewin, a Pacoima resident and member of the Sun Valley Diablos. “Those guys standing behind me, they wanted me dead, but at something like this, they wouldn’t show disrespect to Blinky, so nothing bad will happen.” Rodriguez, who’s put on similar events for a dozen years, breathed a deep sigh of relief as he watched the games play out. “Driving over here, sure, I’m anxious, saying, `Please, Lord, don’t let anything happen,”‘ he said. “But you see them here, playing, getting along. … It couldn’t have turned out better.” brent.hopkins@dailynews.com (818) 713-3738160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img
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Category: qhxhixfebysvahcd MCGUINNESS TO MEET CLUB MANAGERS IN ATTEMPT TO RESOLVE FIXTURE PROBLEMS

first_imgDonegal manager Jim McGuinness will meet with Donegal GAA clubs on Friday to try and provide a solution to the yearly problem regarding club fixtures in the county.  The thorny issue of county players playing club championship while Donegal are still actively involved in the All-Ireland series has again raised it’s head again this year following Donegal’s heavy defeat to Mayo.It is reported that McGuinness wants certain assurances before he commits to another year at the helm as Donegal manager, with the issue of club fixtures believed to be one issue he wants assurances on before he commits to managing in 2014. Donegal county chairman Sean Dunnion believes it will be a good opportunity for both parties to make their feelings clear and hopes a positive solution will come from Friday’s meeting.Donegal supporters will be hoping for a “Good Friday” as nobody wants to see Glenties man step down.Hopefully a solution can be proposed were club players are playing football throughout the summer regularly as it’s not fair on them to only play a handful of games all summer, but it is also imperative that McGuinness has a full deck to choose from when Donegal are in championship action.  MCGUINNESS TO MEET CLUB MANAGERS IN ATTEMPT TO RESOLVE FIXTURE PROBLEMS was last modified: September 4th, 2013 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Club ManagementfixturesFRIDAYJim McGuinnessmeetingnewsproposalSolutionSportlast_img read more

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Category: qhxhixfebysvahcd United vs Chelsea headlines Premier League Match-Day 36

first_img Tags: premier leaguetop Liverpool vs Huddersfield Town Anfield Stadium, LiverpoolFriday, 26-04-2019 @10pmReferee: Kevin FriendLiverpool midfielders Fabinho and Adam Lallana face fitness tests ahead of Friday’s match against Huddersfield. Fabinho sustained a head injury during Sunday’s win at Cardiff, while Lallana has been out for five weeks with a muscle issue.Central defender Dejan Lovren is expected to be available after illness. Huddersfield’s Adama Diakhaby is in contention after a hamstring injury but Aaron Mooy is a doubt and Laurent Depoitre remains out.Liverpool are unbeaten in 13 meetings since a 1-0 defeat 60 years ago (W10, D3). Huddersfield have gone eight games without scoring against Liverpool. Their most recent goal came in a 1-1 draw at Anfield in the Second Division in April 1962.Liverpool could win 10 consecutive matches in all competitions for the first time since a run of 11 in a row under Rafael Benítez from March to May 2006. Their tally of 88 points is a Premier League club record. The most points earned by a team finishing as Premier League runners-up is 89 by Manchester United in 2011-12. They were beaten to the title by Manchester City on goal difference. Liverpool have gone 38 Premier League fixtures without defeat at Anfield, the division’s second longest unbeaten home run behind Chelsea’s 86-match streak. Victory would give the Reds 50 home points in a Premier League season for the first time. Liverpool’s 13 goals from corners is a league-high. Trent Alexander-Arnold’s assist against Cardiff was his 10th of the season, seven of which have come in the last 11 matches. Sadio Mane has scored nine goals in his past eight Premier League appearances at Anfield.Tottenham Hotspurs vs West Ham UnitedTottenham Hotspur Stadium, LondonSaturday, 27-04-2019 @2:30pmReferee: Anthoney TaylorTottenham are hopeful that Dele Alli and Danny Rose will both overcome minor injuries sustained in midweek. Harry Winks and Erik Lamela remain doubts, while Moussa Sissoko, Serge Aurier and Harry Kane are still out.West Ham trio Javier Hernandez, Manuel Lanzini and Aaron Cresswell all face fitness tests after recent injuries. Jack Wilshere is again likely to be named as a substitute as he continues his latest comeback, but Samir Nasri is expected to miss out once more.This will be the third meeting in league and cup this season, with Tottenham winning both prior matches. Spurs are looking to complete their first league double over West Ham since 2012-13. West Ham’s only Premier League away victory at Spurs in the past 16 attempts was by a 3-0 scoreline in October 2013 (D6, L9).Spurs have won all four matches at their new stadium without conceding a goal. They could keep five consecutive home clean sheets in all competitions for the second time under Mauricio Pochettino, having done so from January to February last year at Wembley. The Lilywhites are unbeaten in nine home games, winning eight of them, including fixtures played at Wembley. Tottenham have won all nine home matches against sides currently in the bottom half of the table by an aggregate score of 21-2. Their tally of 19 points in London derbies this season equals the Premier League club record. Mauricio Pochettino is unbeaten in all six home league games as a manager against West Ham (W2, D4).Crystal Palace vs EvertonSelhurst Park, LondonSaturday, 27-04-2019 @5pmReferee: Lee MasonCrystal Palace are weighing up whether to recall Patrick van Aanholt or stick with Joel Ward at left-back. Pape Soaure is out with a minor knock and joins James Tomkins, Mamadou Sakho and Jeffrey Schlupp on the sidelines.Richarlison is a major doubt for Everton because of the rib injury he sustained against Manchester United. Lucas Digne and Yerry Mina have been passed fit but Theo Walcott is struggling with sickness and Andre Gomes remains suspended.Everton are unbeaten in eight meetings since a 3-2 home defeat in September 2014 (W4, D4). Crystal Palace have won only one of nine previous Premier League home matches against Everton and scored just five goals.Fulham vs Cardiff CityCraven Cottage, LondonSaturday, 27-07-2019 @5pmReferee: Chris KavanaghFulham defender Alfie Mawson is in contention to play for the first time since sustaining a knee injury while putting on his boots in late December. Tom Cairney should be available after missing out last weekend following the birth of his child, but Andre Schurrle could be absent for the same reason.Cardiff midfielder Joe Ralls tore his hamstring against Liverpool last week and will not play again this season. Harry Arter has been nursing a calf strain and will be assessed.Fulham suffered their first defeat in eight meetings in all competitions last October when Cardiff won the reverse fixture 4-2. Cardiff have won all three Premier League meetings, including by a 2-1 scoreline at Craven Cottage in 2013. The Bluebirds have scored in 19 successive league matches against Fulham since a 2-0 away defeat in the third tier 30 years ago.Southampton vs AFC Bournemouth St. Mary’s Stadium, HampshireSaturday, 27-04-2019 @5pmReferee: Graham ScottRyan Bertrand is at risk of missing out for Southampton because of an ankle problem, although Matt Targett has resumed full training and could deputise at left-back. Stuart Armstrong faces a fitness test on a hamstring problem.Bournemouth winger Junior Stanislas has been ruled out for at least three months following a hamstring operation. The Cherries remain without injured full-backs Adam Smith, Nathaniel Clyne, Diego Rico and Charlie Daniels.Bournemouth have never won away against Southampton in 14 attempts, drawing five times and losing nine. Southampton’s only defeat in the past 11 encounters came away in the Premier League three years ago (W6, D4).Watford vs WolvesVicarage Road, London Saturday, 27-04-2019 @5pmReferee: Simon HooperWatford are again without captain Troy Deeney, who serves the final game of a three-match suspension. Jose Holebas, Tom Cleverley and Adalberto Penaranda have all been declared fit but Sebastian Prodl and Domingos Quina remain out.Wolves head coach Nuno Espirito Santo has a fully-fit squad at his disposal. Morgan Gibbs-White and Ivan Cavaleiro are among those pushing for a recall should changes be made to the side that beat Arsenal on Wednesday.This fixture comes 20 days after Watford beat Wolves 3-2 in extra-time in their FA Cup semi-final. Watford are looking to complete the league double over Wolves for just the second time, having done so in 2007-08. Wolves are yet to score in three previous top-flight meetings, including October’s 2-0 defeat in the reverse fixture.Brighton and Hove Albion vs Newcastle UnitedThe American Express Community Stadium, East SussexSaturday, 27-04-2019 @7:30pmReferee: Mike DeanWinger Anthony Knockaert is available for Brighton after completing a three-match suspension. Davy Propper is again ruled out with a hamstring problem.Newcastle captain Jamaal Lascelles is ill and will not be involved, while Miguel Almiron will miss the remainder of the season because of a hamstring injury. Fabian Schar and Isaac Hayden, who were substituted with minor injuries last weekend, should both be fit.Newcastle have failed to score in all three Premier League meetings, losing 0-1 twice and drawing the other game 0-0. Brighton won at St James’ Park in October and are looking to complete the league double over Newcastle for the first time since 1978-79.Leicester City vs ArsenalKing Power Stadium, LeicestershireSunday, 28-04-2019 @2pmReferee: Mike OliverLeicester boss Brendan Rodgers has no new injury concerns, with long-term absente Daniel Amartey the only player unavailable. Captain Wes Morgan is back in contention after missing the last game for personal reasons.Arsenal will assess top scorer Pierre-Emerick Aubameyang, who sat out the defeat at Wolves after sinus surgery. Aaron Ramsey and Denis Suarez remain out with respective hamstring and groin problems. Hector Bellerin, Rob Holding and Danny Welbeck continue rehabilitation from serious injuries.Leicester’s 3-1 victory at home last season is their only success in the past 24 Premier League meetings (D7, L16). Arsenal have not lost consecutive away league games against Leicester since defeats there in 1981 and 1983.Arsenal have never lost a Premier League game that has kicked off at midday, winning 15 such matches and drawing four. They could lose three successive top-flight matches for the first time in 13 months. The Gunners are also at risk of conceding at least three goals in three consecutive top-flight matches for the first time since 1967. They have kept just two clean sheets in their last 27 Premier League away games, a sequence spanning 16 months. Gunners boss Unai Emery faced Brendan Rodgers twice in last season’s Champions League group stage, with Emery’s Paris St-Germain side beating Rodgers’ Celtic 7-1 at home and 5-0 away.Burnley vs Manchester CityTurf Moor, BurnleySunday, 28-07-2019 @4:05pmReferee: Paul TierneyBurnley have reported no new injury concerns and could name the same team for a fourth straight match. Peter Crouch, Steven Defour and Aaron Lennon remain out, while Phil Bardsley is doubtful with a gashed leg that has sidelined him for the last three games.Manchester City will assess Fernandinho, who was forced off against Manchester United with a knee problem. City will hope that fellow midfielder Ilkay Gundogan, who suffered a knock in Wednesday’s derby, is available. Kevin de Bruyne remains out with a muscle injury.Manchester City are unbeaten in their last seven league and cup games against Burnley, winning six of those matches. City have only won one of their past three games at Turf Moor (D1, L1), and have failed to keep a clean sheet in any of their four Premier League matches there. The champions have beaten Burnley 5-0 twice this season in all competitions – no team has ever scored five goals against the same opponent three times in a single season in English league history. Seventeen of City’s last 22 league and cup goals against Burnley have come in the second half of matches, including eight of 10 this season.Pep Guardiola’s side have won 11 straight league games, the longest streak in the Premier League this season. They can become the first team to end a top-flight season with 14 consecutive victories, breaking Arsenal’s record of 13 in 2001-02. City have won all 12 of their league matches this season against sides in the bottom seven (prior to the weekend’s matches), scoring a total of 41 goals and conceding just four. Sergio Aguero has scored eight goals in his last seven appearances against Burnley in all competitions. Aguero is one short of becoming the second player to score at least 20 Premier League goals in six different seasons, emulating Alan Shearer (who did so in seven campaigns). Aguero could also become the second player, after Thierry Henry, to achieve this feat in five consecutive seasons.Manchester United vs ChelseaOld Trafford, ManchesterSunday, 28-04-2019 @6:30pmReferee: Martin AtkinsonManchester United midfielder Ander Herrera could return after missing six games with a hamstring injury. Phil Jones and Scott McTominay missed out in midweek and are doubtful for Sunday’s game, but David de Gea will keep his place despite recent errors.Chelsea winger Callum Hudson-Odoi is out for the rest of the season after rupturing his Achilles against Burnley. N’Golo Kante is a doubt after being forced off against the Clarets because of a rib injury. Antonio Rudiger missed that game with a knee injury but is available to return on Sunday.Manchester United can win three consecutive top-flight home games against Chelsea for the first time since 1957. The Londoners have won 18 Premier League matches against United, more than any other side has managed. Chelsea’s six Premier League wins at Old Trafford have come under six different bosses, with five of those victories being the manager’s first league game there with the Blues.United have lost seven of their past nine competitive games for the first time since September to October 1962. That sequence ended on the weekend the Cuban Missile Crisis was resolved. They could lose back-to-back Premier League home matches for just the fifth time. It last happened in March 2014, during David Moyes’ tenure. The Red Devils have failed to score in their last three fixtures – they have not gone four matches without a goal since October to November 1992. Manchester United have played 527 minutes in all competitions since their last goal from open play, scored by Scott McTominay against Wolves. They have gone 12 matches in all competitions without a clean sheet, the club’s longest run since a 16-game streak in 1970.Chelsea have lost six of their seven Premier League fixtures away to sides in the top half of the table this season, with the exception a 2-1 win at Watford on Boxing Day. They are winless in eight league games away to the other clubs from the established top six since beating Tottenham at Wembley in August 2017 (D2, L6). The Blues have won just two of 11 top-flight games this season after conceding the opening goal (D2, L7), with both victories coming against Cardiff. Gonzalo Higuain’s four goals for Chelsea have come against teams currently in the bottom six. He’s played five games and 323 minutes against the top-six sides in all competitions, managing just one shot on target. Kepa Arrizabalaga and Ross Barkley could both make their 50th appearance for the club in all competitions.Comments last_img read more

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Category: qhxhixfebysvahcd Protein Function: It’s All in the Fold

first_imgMost chemical reactions involve atoms or molecules bumping into one another and exchanging electrons.  Proteins, by contrast, derive their immense functional repertoire from their shapes.  Several recent studies explore the amazing potential for strength, motility and catalysis that derives from the way proteins fold.Clots:  A picture of fibrin graces an article in Science Daily.  This protein is responsible for blood clotting.  It has a remarkable property of stretching that comes from unfolding as stresses are applied.  “Understanding blood clot mechanics could help in the design of new treatments not only to prevent or remove clots that cause heart attacks and strokes but also to enhance blood clotting in people with bleeding disorders,” the article said. Muscle stack:  Titin is an appropriately named protein active in muscle.  Its remarkable ability to maintain strength while stretching comes from the way it folds into stacks of sheet-like material.  A commentary in PNAS by Ronald S. Rock described recent work by Bertz et al that shows how another component, telethonin, sitting like a mattress between sheets of titin, contributes to the function.  “What they found was surprising: not only was this the most robust protein or protein complex ever measured, but it also could withstand nearly half the force required to break a covalent bond.  Clearly, there are some unusual features of this complex that lead to its remarkable stability.”  They also found that the strength was dependent on the direction of the force applied.  This led Rock to ask, “With these key structural features identified, can we now engineer these stabilizing interactions where none existed?”  For a popular writeup of these findings, see Science Daily.Imitation as flattery:  Speaking of engineering proteins, an article in Science Daily discussed recent attempts to imitate the folding of DNA and protein for nanotechnology.  A German team said, “we can now build a diversity of three-dimensional nanoscale machine parts, such as round gears or curved tubes or capsules.  Assembling those parts into bigger, more complex and functional devices should be possible.”  A biophysicist on the team added, “We expect many benefits if only we could build super-miniaturized devices on the nanoscale using materials that work robustly in the cells of our bodies – biomolecules such as DNA.”Diverse origami: Science Daily reported on work at Rice University to study the forces that bind proteins together.  In passing the article explained the design of these gems:“Proteins are the workhorses of biology.  Each protein is a string of amino acids that are attached end to end, like a strand of pearls.  The order of the amino acids comes from DNA blueprints, but the order itself doesn’t tell scientists what the protein is designed to do.  That’s because each protein folds in upon itself shortly after its made, much like a strand of pearls curls up as it’s dropped into someone’s palm.    Unlike the pearls, which might fall this way or that depending upon how they’re dropped, proteins fold the same way every time.  That’s important, because when they misfold, they cannot function properly and in some cases can make people sick.No mention was made of how a blind process like evolution could have achieved precision folding of a strand of pearls every time.One-handed trick: Speaking of design, biophysicists at New York University are excited about designing catalysts that can pick out or manufacture one-handed molecules like cells can.  “Many naturally occurring biopolymers (i.e., proteins, RNA, DNA) owe their unique properties to their well-defined three-dimensional structures,” they said in PNAS2  “These attributes have inspired the design and synthesis of folded architectures with functions ranging from molecular recognition to asymmetric catalysis.”  Sure enough, they discovered a way to do this.  The production of an endless supply of optically pure (one-handed) enantiomers (molecules that come in two hands) could have many applications, particularly when these are polymerized into “foldamers” (chains that fold into specific shapes).  “The transfer of chiral information from a folded scaffold can enable the use of a diverse assortment of embedded achiral catalytic centers, promising a generation of synthetic foldamer catalysts for enantioselective transformations that can be performed under a broad range of reaction environments.”  That’s one of the wonders of the cell – the ability to catalyze reactions like this at room temperature.  Techniques they are designing at their Molecular Design Institute are “promising extraordinary versatility for designing catalysts that can be tailored for a broad range of substrates and reaction environments.”That last paper mentioned evolution one time in passing:In living systems, biopolymer catalysts have evolved to accelerate specific biologically relevant transformations.  In contrast, synthetic catalysts must often be designed for nonbiological transformations to be performed in abiotic solvents, pH regimes, temperatures, and pressures that are incompatible with retention of biopolymer structure and activity.  Proteins, however, rely on a limited repertoire of amino acid monomers and require substantial chain lengths to achieve significant structural organization.It’s clear that they did not attempt to explain how “biopolymer catalysts have evolved.”  They also did not discuss the remarkable ability of living systems to distinguish between left- and right-handed members of chiral molecules – a feature absent from non-living systems.  Their work, instead, demonstrates that achieving enantioselectivity by artificial means requires intelligent design.1.  Ronald S. Rock, “A new direction for titin pulling, ” Proceedings of the National Academy of Sciences August 5, 2009, doi: 10.1073/pnas.0906989106.2.  Maayan, Ward and Kirshenbaum, “Folded biomimetic oligomers for enantioselective catalysis,” Proceedings of the National Academy of Sciences, August 10, 2009, doi: 10.1073/pnas.0903187106.A simple study of probability (see online book; also Stephen Meyer’s new book Signature in the Cell) would have convinced the NYU team that enantioselective catalysts made of “substantial chain lengths” could not have evolved.  Living things needed the selectivity before life was even possible.  That would leave only chance as a means getting the catalysts in the first place.  Is that even conceivably possible under ideal conditions?  Read chapter 3 and see.    Evolution collapses in a heap under the selective pressure of detailed investigations into biophysics.  It becomes a tangled web with no function.  In some cases, the misfolded chain of reasoning becomes toxic and can make people sick.  It gums up the works of science, producing a kind of Alzheimer’s syndrome that makes people forget their Maker.  It paralyzes rational thought.  The NYU reference to evolution, following the formula “[complex systems a, b, and c] have evolved,” shows another symptom: the knee jerk reaction.  Pray that uninfected biophysics finds a cure soon for this debilitating malady.(Visited 16 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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